Complement and microglia mediate early synapse loss in Alzheimer mouse models-Reference-Cited by-同舟云学术

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Published:2016-05-06 Issue:6286 Volume:352 Page:712-716
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hong Soyon¹,Beja-Glasser Victoria F.¹,Nfonoyim Bianca M.¹,Frouin Arnaud¹,Li Shaomin²,Ramakrishnan Saranya¹,Merry Katherine M.¹,Shi Qiaoqiao²,Rosenthal Arnon³⁴⁵,Barres Ben A.⁶,Lemere Cynthia A.²,Selkoe Dennis J.²⁷,Stevens Beth¹⁸

Affiliation:

1. F.M. Kirby Neurobiology Center, Boston Children’s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA.

2. Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital (BWH) and HMS, Boston, MA 02115, USA.

3. Alector Inc., 953 Indiana Street, San Francisco, CA 94107, USA.

4. Annexon Biosciences, 280 Utah Avenue Suite 110, South San Francisco, CA 94080, USA.

5. Department of Anatomy, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.

6. Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

7. Prothena Biosciences, Dublin, Ireland.

8. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

Too much cleaning up The complement system and microglia seek out and destroy unwanted cellular debris for the peripheral immune system as well as excess synapses in the developing brain. Hong et al. now show how the system may go haywire in adults early in the progression toward Alzheimer's disease (AD). Aberrant synapse loss is an early feature of Alzheimer's and correlates with cognitive decline. In mice susceptible to AD, complement was associated with synapses, and microglial function was required for synapse loss. The authors speculate that aberrant activation of this “trash disposal” system underlies AD pathology. Science , this issue p. 712

Funder

Edward R. and Anne G. Lefler Fellowship

Coins for Alzheimer's Research Trust

Fidelity Biosciences Research Initiative

JPB Foundation

National Institutes of Health

National Institute of Neurological Disorders and Stroke-NIH

National Institute on Aging-NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary