The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring-Reference-Cited by-同舟云学术

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

Published:2016-02-26 Issue:6276 Volume:351 Page:933-939
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Choi Gloria B.¹,Yim Yeong S.¹,Wong Helen²³,Kim Sangdoo⁴,Kim Hyunju⁴,Kim Sangwon V.⁵,Hoeffer Charles A.²³,Littman Dan R.⁵⁶,Huh Jun R.⁴⁵

Affiliation:

1. The McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Center for Neural Science, New York University, New York, NY 10003, USA.

3. Institute for Behavioral Genetics, Department of Integrated Physiology, University of Colorado, Boulder, CO 80303, USA.

4. Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

5. The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

6. Howard Hughes Medical Institute, New York, NY 10016, USA.

Abstract

A T cell cause for autism? The causes of autism spectrum disorder (ASD) are complex and not entirely clear. Alterations in the mother's immune system during pregnancy, especially during key early periods of fetal neurodevelopment, may play a role. Choi et al. provided infectious or inflammatory stimuli to pregnant mice, which resulted in of spring exhibiting behaviors reminiscent of ASD (see the Perspective by Estes and McAllister). A subset of T helper cells that make the cytokine interleukin-17a in the mothers caused cortical defects and associated ASD behaviors in offspring. Therapeutic targeting of interleukin-17a during gestation reduced ASD symptoms in offspring. Science , this issue p. 933 ; see also p. 919

Funder

Simons Foundation Autism Research Initiative

Simons Foundation to the Simons Center for the Social Brain at Massachusetts Institute of Technology

Robert Buxton

National Research Foundation of Korea

Crohn’s and Colitis Foundation of America

Smith Family Foundation

Searle Scholars Program

Alzheimer's Association

Brain and Behavior Research Foundation (NARSAD)

NIH

Howard Hughes Medical Institute