An anatomic transcriptional atlas of human glioblastoma

Author:

Puchalski Ralph B.12ORCID,Shah Nameeta23ORCID,Miller Jeremy1,Dalley Rachel1,Nomura Steve R.2ORCID,Yoon Jae-Guen2ORCID,Smith Kimberly A.1,Lankerovich Michael2ORCID,Bertagnolli Darren1ORCID,Bickley Kris1ORCID,Boe Andrew F.1,Brouner Krissy1ORCID,Butler Stephanie1,Caldejon Shiella1,Chapin Mike1ORCID,Datta Suvro1,Dee Nick1ORCID,Desta Tsega1ORCID,Dolbeare Tim1,Dotson Nadezhda1ORCID,Ebbert Amanda1,Feng David1ORCID,Feng Xu4ORCID,Fisher Michael1,Gee Garrett1,Goldy Jeff1ORCID,Gourley Lindsey1,Gregor Benjamin W.1ORCID,Gu Guangyu1ORCID,Hejazinia Nika1ORCID,Hohmann John1,Hothi Parvinder2,Howard Robert1,Joines Kevin1ORCID,Kriedberg Ali1,Kuan Leonard1,Lau Chris1,Lee Felix1ORCID,Lee Hwahyung2,Lemon Tracy1,Long Fuhui1,Mastan Naveed1ORCID,Mott Erika1,Murthy Chantal2ORCID,Ngo Kiet1,Olson Eric1,Reding Melissa1ORCID,Riley Zack1ORCID,Rosen David1,Sandman David1ORCID,Shapovalova Nadiya1ORCID,Slaughterbeck Clifford R.1ORCID,Sodt Andrew1,Stockdale Graham1ORCID,Szafer Aaron1ORCID,Wakeman Wayne1,Wohnoutka Paul E.1ORCID,White Steven J.5ORCID,Marsh Don5ORCID,Rostomily Robert C.67,Ng Lydia1,Dang Chinh1,Jones Allan1,Keogh Bart4,Gittleman Haley R.8,Barnholtz-Sloan Jill S.8ORCID,Cimino Patrick J.9ORCID,Uppin Megha S.10,Keene C. Dirk9ORCID,Farrokhi Farrokh R.11ORCID,Lathia Justin D.12,Berens Michael E.13ORCID,Iavarone Antonio141516,Bernard Amy1,Lein Ed1ORCID,Phillips John W.1,Rostad Steven W.17ORCID,Cobbs Charles2,Hawrylycz Michael J.1ORCID,Foltz Greg D.2

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA 98109, USA.

2. Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.

3. Mazumdar Shaw Center for Translational Research, Bangalore 560099, India.

4. Radia Inc., Lynnwood, WA 98036, USA.

5. White Marsh Forests, Seattle, WA 98119, USA.

6. Department of Neurosurgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

7. Department of Neurological Surgery, Houston Methodist Hospital and Research Institute, Houston, TX 77030, USA.

8. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

9. Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.

10. Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.

11. Virginia Mason Medical Center, Seattle, WA 98101, USA.

12. Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

13. TGen, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

14. Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.

15. Department of Neurology, Columbia University, New York, NY 10032, USA.

16. Department of Pathology, Columbia University, New York, NY 10032, USA.

17. CellNetix, Seattle, WA 98122, USA.

Abstract

Anatomically correct tumor genomics Glioblastoma is the most lethal form of human brain cancer. The genomic alterations and gene expression profiles characterizing this tumor type have been widely studied. Puchalski et al. created the Ivy Glioblastoma Atlas, a freely available online resource for the research community. The atlas, a collaborative effort between bioinformaticians and pathologists, maps molecular features of glioblastomas, such as transcriptional signatures, to histologically defined anatomical regions of the tumors. The relationships identified in this atlas, in conjunction with associated databases of clinical and genomic information, could provide new insights into the pathogenesis, diagnosis, and treatment of glioblastoma. Science , this issue p. 660

Funder

Ben and Catherine Ivy Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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