An anatomic transcriptional atlas of human glioblastoma-Reference-Cited by-同舟云学术

An anatomic transcriptional atlas of human glioblastoma

Published:2018-05-11 Issue:6389 Volume:360 Page:660-663
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Puchalski Ralph B.¹²^ORCID,Shah Nameeta²³^ORCID,Miller Jeremy¹,Dalley Rachel¹,Nomura Steve R.²^ORCID,Yoon Jae-Guen²^ORCID,Smith Kimberly A.¹,Lankerovich Michael²^ORCID,Bertagnolli Darren¹^ORCID,Bickley Kris¹^ORCID,Boe Andrew F.¹,Brouner Krissy¹^ORCID,Butler Stephanie¹,Caldejon Shiella¹,Chapin Mike¹^ORCID,Datta Suvro¹,Dee Nick¹^ORCID,Desta Tsega¹^ORCID,Dolbeare Tim¹,Dotson Nadezhda¹^ORCID,Ebbert Amanda¹,Feng David¹^ORCID,Feng Xu⁴^ORCID,Fisher Michael¹,Gee Garrett¹,Goldy Jeff¹^ORCID,Gourley Lindsey¹,Gregor Benjamin W.¹^ORCID,Gu Guangyu¹^ORCID,Hejazinia Nika¹^ORCID,Hohmann John¹,Hothi Parvinder²,Howard Robert¹,Joines Kevin¹^ORCID,Kriedberg Ali¹,Kuan Leonard¹,Lau Chris¹,Lee Felix¹^ORCID,Lee Hwahyung²,Lemon Tracy¹,Long Fuhui¹,Mastan Naveed¹^ORCID,Mott Erika¹,Murthy Chantal²^ORCID,Ngo Kiet¹,Olson Eric¹,Reding Melissa¹^ORCID,Riley Zack¹^ORCID,Rosen David¹,Sandman David¹^ORCID,Shapovalova Nadiya¹^ORCID,Slaughterbeck Clifford R.¹^ORCID,Sodt Andrew¹,Stockdale Graham¹^ORCID,Szafer Aaron¹^ORCID,Wakeman Wayne¹,Wohnoutka Paul E.¹^ORCID,White Steven J.⁵^ORCID,Marsh Don⁵^ORCID,Rostomily Robert C.⁶⁷,Ng Lydia¹,Dang Chinh¹,Jones Allan¹,Keogh Bart⁴,Gittleman Haley R.⁸,Barnholtz-Sloan Jill S.⁸^ORCID,Cimino Patrick J.⁹^ORCID,Uppin Megha S.¹⁰,Keene C. Dirk⁹^ORCID,Farrokhi Farrokh R.¹¹^ORCID,Lathia Justin D.¹²,Berens Michael E.¹³^ORCID,Iavarone Antonio¹⁴¹⁵¹⁶,Bernard Amy¹,Lein Ed¹^ORCID,Phillips John W.¹,Rostad Steven W.¹⁷^ORCID,Cobbs Charles²,Hawrylycz Michael J.¹^ORCID,Foltz Greg D.²

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA 98109, USA.

2. Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.

3. Mazumdar Shaw Center for Translational Research, Bangalore 560099, India.

4. Radia Inc., Lynnwood, WA 98036, USA.

5. White Marsh Forests, Seattle, WA 98119, USA.

6. Department of Neurosurgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

7. Department of Neurological Surgery, Houston Methodist Hospital and Research Institute, Houston, TX 77030, USA.

8. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

9. Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.

10. Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.

11. Virginia Mason Medical Center, Seattle, WA 98101, USA.

12. Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

13. TGen, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

14. Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.

15. Department of Neurology, Columbia University, New York, NY 10032, USA.

16. Department of Pathology, Columbia University, New York, NY 10032, USA.

17. CellNetix, Seattle, WA 98122, USA.

Abstract

Anatomically correct tumor genomics Glioblastoma is the most lethal form of human brain cancer. The genomic alterations and gene expression profiles characterizing this tumor type have been widely studied. Puchalski et al. created the Ivy Glioblastoma Atlas, a freely available online resource for the research community. The atlas, a collaborative effort between bioinformaticians and pathologists, maps molecular features of glioblastomas, such as transcriptional signatures, to histologically defined anatomical regions of the tumors. The relationships identified in this atlas, in conjunction with associated databases of clinical and genomic information, could provide new insights into the pathogenesis, diagnosis, and treatment of glioblastoma. Science , this issue p. 660

Funder

Ben and Catherine Ivy Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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