Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia-Reference-Cited by-全球学者库

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

Published:2016-01 Issue:6268 Volume:351 Page:81-84
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sabir Jamal S. M.¹,Lam Tommy T.-Y.²³⁴,Ahmed Mohamed M. M.¹⁵,Li Lifeng³⁴,Shen Yongyi³⁴,E. M. Abo-Aba Salah¹⁶,Qureshi Muhammd I.¹,Abu-Zeid Mohamed¹⁶,Zhang Yu²³⁴,Khiyami Mohammad A.⁷,Alharbi Njud S.¹,Hajrah Nahid H.¹,Sabir Meshaal J.¹,Mutwakil Mohammed H. Z.¹,Kabli Saleh A.¹,Alsulaimany Faten A. S.¹,Obaid Abdullah Y.⁸,Zhou Boping²,Smith David K.⁴,Holmes Edward C.⁹,Zhu Huachen²³⁴,Guan Yi¹²³⁴

Affiliation:

1. Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

2. State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong–Shenzhen Branch), Shenzhen Third People’s Hospital, Shenzhen, China.

3. Shantou University–The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China.

4. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.

5. Department of Nucleic Acids Research, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, Borg El-Arab, Post Office Box 21934, Alexandria, Egypt.

6. Microbial Genetics Department, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza, Egypt.

7. King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.

8. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

9. Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia.

Abstract

Coronaviruses in the Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness and kills about a third of people infected. The virus is common in dromedary camels, which can be a source of human infections. In a survey for MERSCoV in over 1300 Saudi Arabian camels, Sabir et al. found that dromedaries share three coronavirus species with humans. Diverse MERS lineages in camels have caused human infections, which suggests that transfer among host species occurs quite easily. Haagmans et al. made a MERS-CoV vaccine for use in camels, using poxvirus as a vehicle. The vaccine significantly reduced virus excretion, which should help reduce the potential for transmission to humans, and conferred cross-immunity to camelpox infections. Science , this issue p. 81 , p. 77

Funder

Deanship of Scientific Research

Shenzhen Peacock Plan High-End Talents Program

Li Ka Shing Foundation

Theme-based Research Scheme

National Health and Medical Research Council of Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia