Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes-Reference-Cited by-全球学者库

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Published:2018-03-09 Issue:6380 Volume:359 Page:1151-1156
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhao Liping¹²^ORCID,Zhang Feng¹^ORCID,Ding Xiaoying³^ORCID,Wu Guojun¹,Lam Yan Y.²^ORCID,Wang Xuejiao³,Fu Huaqing¹,Xue Xinhe¹,Lu Chunhua⁴,Ma Jilin⁴,Yu Lihua⁴,Xu Chengmei⁴,Ren Zhongying⁴,Xu Ying⁵,Xu Songmei⁵,Shen Hongli⁵,Zhu Xiuli⁵,Shi Yu⁶,Shen Qingyun⁶,Dong Weiping³,Liu Rui¹,Ling Yunxia³,Zeng Yue⁷,Wang Xingpeng⁷,Zhang Qianpeng¹,Wang Jing¹^ORCID,Wang Linghua¹,Wu Yanqiu¹,Zeng Benhua⁸,Wei Hong⁸,Zhang Menghui¹,Peng Yongde³^ORCID,Zhang Chenhong¹^ORCID

Affiliation:

1. State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

2. Department of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers University, NJ 08901, USA.

3. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

4. Sijing Community Health Service Center of Songjiang District, Shanghai 201601, China.

5. Sijing Hospital of Songjiang District, Shanghai 201601, China.

6. Department of Endocrinology and Metabolism, Qidong People’s Hospital, Jiangsu 226200, China.

7. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

8. Department of Laboratory Animal Science, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.

Abstract

Microbial modulation of diabetes Short-chain fatty acids (SCFAs) are produced by various human gut microbes. SCFAs act as an energy source to the colonic epithelium and are also sensed by host signaling pathways that modulate appetite and inflammation. Deficiency of gut SCFAs is associated with type 2 diabetes. Zhao et al. found that adopting a high-fiber diet promoted the growth of SCFA-producing organisms in diabetic humans. The high-fiber diet induced changes in the entire gut microbe community and correlated with elevated levels of glucagon-like peptide-1, a decline in acetylated hemoglobin levels, and improved blood-glucose regulation. Science , this issue p. 1151

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Key Projects of Shanghai Municipal Health Bureau Research Fund

Shanghai Jiao Tong University Research Funding on Medical and Engineering Interdisciplinary Projects

Songjiang District Health Bureau of Climbing Medical Program

Shanghai Shen Kang Hospital Development Center for chronic disease prevention and control project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.