Requirement of Mammalian Timeless for Circadian Rhythmicity-Reference-Cited by-同舟云学术

Requirement of Mammalian Timeless for Circadian Rhythmicity

Published:2003-10-17 Issue:5644 Volume:302 Page:439-442
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Barnes Jessica W.¹²,Tischkau Shelley A.¹²,Barnes Jeffrey A.¹²,Mitchell Jennifer W.¹²,Burgoon Penny W.¹²,Hickok Jason R.¹²,Gillette Martha U.¹²

Affiliation:

1. Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2. Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

Abstract

Despite a central circadian role in Drosophila for the transcriptional regulator Timeless ( dTim ), the relevance of mammalian Timeless ( mTim ) remains equivocal. Conditional knockdown of mTim protein expression in the rat suprachiasmatic nucleus (SCN) disrupted SCN neuronal activity rhythms, and altered levels of known core clock elements. Full-length mTim protein (mTIM-fl) exhibited a 24-hour oscillation, where as a truncated isoform (mTIM-s) was constitutively expressed. mTIM-fl associated with the mammalian clock Period proteins (mPERs) in oscillating SCN cells. These data suggest that mTim is required for rhythmicity and is a functional homolog of dTim on the negative-feedback arm of the mammalian molecular clockwork.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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