Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior-Reference-Cited by-同舟云学术

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

Published:2019-08-30 Issue:6456 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ganna Andrea¹²³⁴^ORCID,Verweij Karin J. H.⁵^ORCID,Nivard Michel G.⁶,Maier Robert¹²³^ORCID,Wedow Robbee¹³⁷⁸⁹^ORCID,Busch Alexander S.¹⁰¹¹¹²^ORCID,Abdellaoui Abdel⁵,Guo Shengru¹³,Sathirapongsasuti J. Fah¹⁴^ORCID,Lichtenstein Paul⁴^ORCID,Lundström Sebastian¹⁵,Långström Niklas⁴^ORCID,Auton Adam¹⁴^ORCID,Harris Kathleen Mullan¹⁶¹⁷^ORCID,Beecham Gary W.¹³,Martin Eden R.¹³,Sanders Alan R.¹⁸¹⁹^ORCID,Perry John R. B.¹⁰^ORCID,Neale Benjamin M.¹²³^ORCID,Zietsch Brendan P.²⁰^ORCID,

Affiliation:

1. Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

4. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

5. Department of Psychiatry, Amsterdam University Medical Centers (UMC), location AMC, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, Netherlands.

6. Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, Netherlands.

7. Department of Sociology, Harvard University, Cambridge, MA 02138, USA.

8. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

9. Department of Sociology, University of Colorado, Boulder, CO 80309-0483, USA.

10. Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

11. Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

12. International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen, Denmark.

13. Department of Human Genetics, University of Miami, Miami, FL 33136, USA.

14. 23andMe, Mountain View, CA 94041, USA.

15. Centre for Ethics, Law and Mental Health, Gillberg Neuropsychiatry Centre, University of Gothenburg, Sweden.

16. Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.

17. Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

18. Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA.

19. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA.

20. Centre for Psychology and Evolution, School of Psychology, University of Queensland, St. Lucia, Brisbane QLD 4072, Australia.

Abstract

The genetics of sexual orientation Twin studies and other analyses of inheritance of sexual orientation in humans has indicated that same-sex sexual behavior has a genetic component. Previous searches for the specific genes involved have been underpowered and thus unable to detect genetic signals. Ganna et al. perform a genome-wide association study on 493,001 participants from the United States, the United Kingdom, and Sweden to study genes associated with sexual orientation (see the Perspective by Mills). They find multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, nonheterosexual behavior is polygenic. Science , this issue p. eaat7693 ; see also p. 869

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Netherlands Organisation for Health Research and Development

Swedish council for working life and social research

Swedish Research Council for Health, Working Life and Welfare

the Australian Research Council

Knut and Alice Wallenberg foundation

National Science Foundation’s Graduate Research Fellowship Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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