Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts-Reference-Cited by-同舟云学术

Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts

Published:2015-06-26 Issue:6242 Volume:348 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jain Rajan¹,Li Deqiang¹,Gupta Mudit¹,Manderfield Lauren J.¹,Ifkovits Jamie L.¹,Wang Qiaohong¹,Liu Feiyan¹,Liu Ying¹,Poleshko Andrey¹,Padmanabhan Arun¹,Raum Jeffrey C.²,Li Li¹,Morrisey Edward E.¹,Lu Min Min¹,Won Kyoung-Jae²,Epstein Jonathan A.¹

Affiliation:

1. Department of Cell and Developmental Biology, Penn Cardiovascular Institute, Institute of Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Genetics, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, the identity of a marker specific to cardiomyocyte formation has been elusive. Jain et al. now identify a specialized progenitor population that is committed exclusively to forming cardiomyocytes. They also identify the niche signals that promote lineage commitment and the mechanisms involved in making cardiomyocytes. The findings may help in the development of future cell-based regenerative therapeutics for heart disease. Science , this issue 10.1126/science.aaa6071

Funder

NIH

Cotswold Foundation

Spain Fund for Regenerative Cardiology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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