The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host

Author:

Russell Colin A.123,Fonville Judith M.12,Brown André E. X.4,Burke David F.12,Smith David L.356,James Sarah L.12,Herfst Sander7,van Boheemen Sander7,Linster Martin7,Schrauwen Eefje J.7,Katzelnick Leah12,Mosterín Ana128,Kuiken Thijs7,Maher Eileen9,Neumann Gabriele9,Osterhaus Albert D. M. E.7,Kawaoka Yoshihiro9101112,Fouchier Ron A. M.7,Smith Derek J.1237

Affiliation:

1. Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

2. World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK.

3. Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.

4. Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

5. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

6. Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

7. Department of Virology, Erasmus Medical Center, Rotterdam 3015 CE, the Netherlands.

8. Center for Research in Health and Economics, Universitat Pompeu Fabra, Barcelona 08005, Spain.

9. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.

10. Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

11. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

12. Exploratory Research for Advanced Technology (ERATO) Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 102-0076, Japan.

Abstract

Some natural influenza viruses need only three amino acid substitutions to acquire airborne transmissibility between mammals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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