The microbial metabolite desaminotyrosine protects from influenza through type I interferon-Reference-Cited by-同舟云学术

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Published:2017-08-04 Issue:6350 Volume:357 Page:498-502
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Steed Ashley L.¹²^ORCID,Christophi George P.³²^ORCID,Kaiko Gerard E.²^ORCID,Sun Lulu²^ORCID,Goodwin Victoria M.¹²^ORCID,Jain Umang²,Esaulova Ekaterina²⁴^ORCID,Artyomov Maxim N.²,Morales David J.³²^ORCID,Holtzman Michael J.³,Boon Adrianus C. M.³²⁵^ORCID,Lenschow Deborah J.³²^ORCID,Stappenbeck Thaddeus S.²^ORCID

Affiliation:

1. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Computer Technologies Department, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg 197101, Russia.

5. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Eat more plants for influenza resilience Antibiotic treatment worsens influenza in mice, possibly because the concomitant loss of the microbiota interrupts the production of bioactive metabolites. Steed et al. found that a microbial product, desaminotyrosine (DAT), produced by an obligate clostridial anaerobe from the digestion of plant flavonoids, is beneficial during influenza. DAT enters the bloodstream and triggers type I interferon signaling, which then augments antiviral responses by phagocytic cells. Without DAT, influenza virus causes inflammation and severe disease. Science , this issue p. 498

Funder

Crohn’s Colitis

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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