Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation-Reference-Cited by-同舟云学术

Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation

Published:2017-10-20 Issue:6361 Volume:358 Page:359-365
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Atarashi Koji¹²^ORCID,Suda Wataru¹³⁴^ORCID,Luo Chengwei⁵⁶,Kawaguchi Takaaki¹²^ORCID,Motoo Iori²,Narushima Seiko²^ORCID,Kiguchi Yuya³^ORCID,Yasuma Keiko¹^ORCID,Watanabe Eiichiro²^ORCID,Tanoue Takeshi¹²,Thaiss Christoph A.⁷,Sato Mayuko⁸^ORCID,Toyooka Kiminori⁸^ORCID,Said Heba S.⁴⁹,Yamagami Hirokazu¹⁰,Rice Scott A.¹¹^ORCID,Gevers Dirk⁵^ORCID,Johnson Ryan C.¹²^ORCID,Segre Julia A.¹²^ORCID,Chen Kong¹³^ORCID,Kolls Jay K.¹³,Elinav Eran⁷,Morita Hidetoshi¹⁴,Xavier Ramnik J.⁵⁶^ORCID,Hattori Masahira³⁴^ORCID,Honda Kenya¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

2. RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

3. Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan.

4. Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

5. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

6. Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

7. Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.

8. RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

9. Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

10. Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

11. The Singapore Centre for Environmental Life Sciences Engineering, The School of Biological Sciences, Nanyang Technological University, Singapore.

12. Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

13. Richard King Mellon Foundation Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

14. Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan

Abstract

Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbe community. The causes of these intractable diseases have been difficult to discern. Atarashi et al. took samples from the mouths of IBD and CD patients and inoculated the extracted bacteria into germ-free mice (see the Perspective by Cao). Some of the inoculated mice showed strong proliferation of T helper 1 cells associated with the establishment of oral Klebsiella species in the colon. Klebsiella can be resistant to multiple antibiotics and are able to replace normal colon microbes after antibiotic therapy. Now we know that they probably originate from the mouth and could potentially contribute to bowel disease. Science , this issue p. 359 ; see also p. 308

Funder

Japan Agency for Medical Research and Development

NIH

the Takeda Science Foundation

the Uehara Memorial Foundation

The Mitsubishi Foundation

Helmsley Charitable Trust and Crohn’s colitis foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.