Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques-Reference-Cited by-全球学者库

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Published:2020-07-02 Issue:6505 Volume:369 Page:818-823
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Deng Wei¹^ORCID,Bao Linlin¹^ORCID,Liu Jiangning¹^ORCID,Xiao Chong¹^ORCID,Liu Jiayi²^ORCID,Xue Jing¹^ORCID,Lv Qi¹,Qi Feifei¹,Gao Hong¹^ORCID,Yu Pin¹^ORCID,Xu Yanfeng¹^ORCID,Qu Yajin¹^ORCID,Li Fengdi¹,Xiang Zhiguang¹^ORCID,Yu Haisheng¹^ORCID,Gong Shuran¹,Liu Mingya¹,Wang Guanpeng¹,Wang Shunyi¹^ORCID,Song Zhiqi¹^ORCID,Liu Ying¹^ORCID,Zhao Wenjie¹^ORCID,Han Yunlin¹^ORCID,Zhao Linna¹^ORCID,Liu Xing¹^ORCID,Wei Qiang¹^ORCID,Qin Chuan¹^ORCID

Affiliation:

1. Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.

2. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Abstract

Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.

Funder

National key research and development project of China

National Mega projects of China for Major Infectious Diseases

CAMS Initiative for Innovative Medicine of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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