Helicobacter pylori Virulence and Genetic Geography-Reference-Cited by-同舟云学术

Helicobacter pylori Virulence and Genetic Geography

Published:1999-05-21 Issue:5418 Volume:284 Page:1328-1333
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Covacci Antonello¹,Telford John L.¹,Giudice Giuseppe Del¹,Parsonnet Julie²,Rappuoli Rino¹

Affiliation:

1. IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.

2. Department of Medicine/Infectious Diseases Hrp T152, Stanford University, CA 94305, USA.

Abstract

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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