Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain-Reference-Cited by-同舟云学术

Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain

Published:2021-06-11 Issue:6547 Volume:372 Page:1205-1209
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Delgado Ana C.¹^ORCID,Maldonado-Soto Angel R.²^ORCID,Silva-Vargas Violeta¹,Mizrak Dogukan³⁴,von Känel Thomas¹^ORCID,Tan Kelly R.¹^ORCID,Paul Alex⁵^ORCID,Madar Aviv⁶,Cuervo Henar⁷^ORCID,Kitajewski Jan⁷^ORCID,Lin Chyuan-Sheng³⁸^ORCID,Doetsch Fiona¹^ORCID

Affiliation:

1. Biozentrum, University of Basel, Basel, Switzerland.

2. Department of Neurology, Columbia University, New York, NY, USA.

3. Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.

4. Department of Systems Biology, Columbia University, New York, NY, USA.

5. Department of Genetics and Development, Columbia University, New York, NY, USA.

6. Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.

7. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA.

8. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.

Abstract

Gliogenesis in the adult mouse brain Neural stem cells in the adult mouse brain can generate both neurons and glia. Exactly where each stem cell is positioned can determine what type of neurons it generates. Delgado et al. show that neural stem cells are also choosy about what sorts of glia they make and when (see the Perspective by Baldwin and Silver). Injury or selective deletion of platelet-derived growth factor receptor β (PDGFRβ) from the stem cells kicked them into overdrive and revealed their selectivity with respect to gliogenesis. An unusual type of glial progenitor cell, intraventricular oligodendrocyte progenitors, are found nestled between the cilia of ependymal cells derived from tight clusters of PDGFRβ-expressing stem cells. Science , abg8467, this issue p. 1205 ; see also abj1139, p. 1151

Funder

National Institutes of Health

National Cancer Institute

European Research Council

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

2. Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche