Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation-Reference-Cited by-同舟云学术

Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation

Published:2016-05-13 Issue:6287 Volume:352 Page:812-816
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Boyce Richard¹,Glasgow Stephen D.²,Williams Sylvain²,Adamantidis Antoine²³

Affiliation:

1. Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.

2. Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

3. Department of Neurology and Department of Clinical Research, Inselspital University Hospital, University of Bern, Bern, Switzerland.

Abstract

Let sleeping mice remember The role of REM (rapid eye movement) sleep for memory consolidation has been discussed for a long time. Boyce et al. used optogenetics to inhibit theta oscillations in the mouse hippocampus during REM sleep (see the Perspective by Kocsis). Both object recognition memory and contextual fear memory were impaired. This consolidation mechanism occurred in a critical time window immediately after training. Disrupting the same system for similar durations during non-REM sleep or wakefulness had no effect on memory. Science , this issue p. 812 ; see also p. 770

Funder

Alexander Graham Bell Canada

Natural Sciences and Engineering Research Council of Canada (NSERC)

Fonds de la Recherche en Sante du Quebec

Canadian Institutes of Health Research (CIHR)

Human Frontier Science Program

Douglas Foundation

McGill University

Canadian Fund for Innovation (CFI)

Canadian Research Chair

CIHR

NSERC