Topographical and Temporal Diversity of the Human Skin Microbiome

Author:

Grice Elizabeth A.1,Kong Heidi H.2,Conlan Sean1,Deming Clayton B.1,Davis Joie3,Young Alice C.4,Bouffard Gerard G.45,Blakesley Robert W.45,Murray Patrick R.6,Green Eric D.45,Turner Maria L.2,Segre Julia A.1,

Affiliation:

1. Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.

2. Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

3. Office of Translational Research, National Human Genome Research Institute, Bethesda, MD 20892, USA.

4. NIH Intramural Sequencing Center, National Human Genome Research Institute, Bethesda, MD 20892, USA.

5. Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.

6. Clinical Microbiology Laboratory, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA.

Abstract

The Close and Personal Biome Fortunately, our skin is readily accessible for ecological studies of the microbial communities that influence health and disease states. Grice et al. (p. 1190 ) present a metagenomic survey of body sites from 10 healthy human individuals sampled over time. Although, altogether 18 phyla were discovered, only a few predominated. The most diverse communities were found on the forearm and the least behind the ear, but between people the microorganisms living behind the knees, in the elbow, and behind the ear were most similar. This finding might have some bearing on the common occurrence of atopic dermatitis in these zones, although no similar relationship was discerned between skin microbial flora and psoriasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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