Comprehensive serological profiling of human populations using a synthetic human virome

Author:

Xu George J.1234,Kula Tomasz345,Xu Qikai34,Li Mamie Z.34,Vernon Suzanne D.6,Ndung’u Thumbi78910,Ruxrungtham Kiat11,Sanchez Jorge12,Brander Christian13,Chung Raymond T.14,O’Connor Kevin C.15,Walker Bruce89,Larman H. Benjamin16,Elledge Stephen J.346

Affiliation:

1. Program in Biophysics, Harvard University, Cambridge, MA 02115, USA.

2. Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

3. Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.

4. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.

5. Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02115, USA.

6. Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.

7. KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

8. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa.

9. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.

10. Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany.

11. Vaccine and Cellular Immunology Laboratory, Department of Medicine, Faculty of Medicine; and Chula-Vaccine Research Center, Chulalongkorn University, Bangkok, Thailand.

12. Asociación Civil IMPACTA Salud y Educación, Lima, Peru.

13. AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

14. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

15. Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.

16. Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

Viral exposure—the complete history In addition to causing illness, viruses leave indelible footprints behind, because infection permanently alters the immune system. Blood tests that detect antiviral antibodies can provide information about both past and present viral exposures. Typically, such tests measure only one virus at a time. Using a synthetic representation of all human viral peptides, Xu et al. developed a blood test that identifies antibodies against all known human viruses. They studied blood samples from nearly 600 people of differing ages and geographic locations and found that most had been exposed to about 10 viral species over their lifetime. Despite differences in the rates of exposure to specific viruses, the antibody responses in most individuals targeted the same viral epitopes. Science , this issue 10.1126/science.aaa0698

Funder

NIH

Howard Hughes Medical Institute

International AIDS Vaccine Initiative

Thailand Research Fund

South African Research Chairs Initiative

Victor Daitz Foundation

NIH–National Institute of Dental and Craniofacial Research

HIVACAT

CUTHIVAC

Chulalongkorn University Research Professor Program, Thailand

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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