MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing-Reference-Cited by-同舟云学术

MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing

Published:2012-06-15 Issue:6087 Volume:336 Page:1448-1451
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moissiard Guillaume¹,Cokus Shawn J.¹,Cary Joshua¹,Feng Suhua¹,Billi Allison C.²,Stroud Hume¹,Husmann Dylan¹,Zhan Ye³,Lajoie Bryan R.³,McCord Rachel Patton³,Hale Christopher J.¹,Feng Wei⁴,Michaels Scott D.⁴,Frand Alison R.⁵,Pellegrini Matteo¹⁶,Dekker Job³,Kim John K.²,Jacobsen Steven E.¹⁵⁶⁷

Affiliation:

1. Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Terasaki Life Sciences Building, 610 Charles Young Drive East, Los Angeles, CA 90095–723905, USA.

2. Life Sciences Institute and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

3. Lazare Research Building 570N, Program in Systems Biology and Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

4. Department of Biology, Indiana University, Bloomington, IN 47405, USA.

5. Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

6. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.

7. Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract

To Silence or Not to Silence Repressed genes commonly have methylated DNA, and/or covalent histone modifications associated with silent chromatin, and/or associated small interfering (si)RNAs. All three features are components of gene-silencing systems (see the Perspective by

Jacob and Martienssen

). In a screen for components of DNA methylation gene-silencing systems in the flowering plant, Moissiard et al. (p. 1448 , published online 3 May) identified the genes AtMoRC1 and AtMORC6 , which are homologs of the mouse Microrchidia1 gene. AtMORC1 and AtMORC6 are involved in silencing transposable elements and genes corresponding to DNA-methylated loci, and yet neither gene is required for maintenance of DNA methylation. Instead, AtMoRC1 and AtMORC6 are related to proteins that remodel chromatin superstructure, and they seem to control gene-silencing through the higher-order compaction of methylated and silent chromatin. Qian et al. (p. 1445 ) identified an Arabidopsis gene, IDM1 (increased DNA methylation 1), that is involved in regulating DNA methylation at loci enriched for repeats and multigene families containing highly homologous genes. IDM1 protects target genes from DNA silencing and recognizes both histone H3 and methylated DNA at target loci and is able to acetylate histone H3.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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