Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy-Reference-Cited by-同舟云学术

Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

Published:1997-02-07 Issue:5301 Volume:275 Page:838-841
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Choi-Lundberg Derek L.¹,Lin Qing¹,Chang Yung-Nien²,Chiang Yawen L.²,Hay Carl M.²,Mohajeri Hasan¹,Davidson Beverly L.³,Bohn Martha C.¹

Affiliation:

1. D. L. Choi-Lundberg, Q. Lin, H. Mohajeri, M. C. Bohn, Department of Neurobiology and Anatomy, University of Rochester, Box B603, 601 Elmwood Avenue, Rochester, NY 14642, USA.

2. Y.-N. Chang, Y. L. Chiang, C. M. Hay, Genetic Therapy, 19 First Field Road, Gaithersburg, MD 20878, USA.

3. B. L. Davidson, Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Abstract

Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

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