Diabetes, Obesity, and the Brain-Reference-Cited by-同舟云学术

Diabetes, Obesity, and the Brain

Published:2005-01-21 Issue:5708 Volume:307 Page:375-379
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schwartz Michael W.¹²³⁴,Porte Daniel¹²³⁴

Affiliation:

1. Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98110, USA.

2. Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98110, USA.

3. Division of Metabolism, Diabetes and Endocrinology, University of California San Diego, San Diego, CA 92161, USA.

4. Division of Metabolism, Diabetes and Endocrinology, VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

Abstract

Recent evidence suggests a key role for the brain in the control of both body fat content and glucose metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. Defects in this control system are implicated in the link between obesity and type 2 diabetes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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