Human telomere length is chromosome end–specific and conserved across individuals-Reference-Cited by-同舟云学术

Human telomere length is chromosome end–specific and conserved across individuals

Published:2024-05-03 Issue:6695 Volume:384 Page:533-539
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Karimian Kayarash¹²^ORCID,Groot Aljona³^ORCID,Huso Vienna¹²^ORCID,Kahidi Ramin⁴^ORCID,Tan Kar-Tong⁵⁶⁷^ORCID,Sholes Samantha¹²^ORCID,Keener Rebecca²⁸^ORCID,McDyer John F.⁹^ORCID,Alder Jonathan K.⁹^ORCID,Li Heng¹⁰¹¹^ORCID,Rechtsteiner Andreas³^ORCID,Greider Carol W.¹³^ORCID

Affiliation:

1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

2. Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

3. Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.

4. Health Sciences Program, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

5. Department of Genetics, Harvard Medical School, Boston, MA, USA.

6. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

7. Cancer Program, The Broad Institute, Cambridge, MA, USA.

8. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

9. Pulmonary, Allergy, Critical Care, and Sleep Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

10. Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.

11. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

Abstract

Short telomeres cause age-related disease, and long telomeres contribute to cancer; however, the mechanisms regulating telomere length are unclear. We developed a nanopore-based method, which we call Telomere Profiling, to determine telomere length at nearly single-nucleotide resolution. Mapping telomere reads to chromosome ends showed chromosome end–specific length distributions that could differ by more than six kilobases. Examination of telomere lengths in 147 individuals revealed that certain chromosome ends were consistently longer or shorter. The same rank order was found in newborn cord blood, suggesting that telomere length is determined at birth and that chromosome end–specific telomere length differences are maintained as telomeres shorten with age. Telomere Profiling makes precision investigation of telomere length widely accessible for laboratory, clinical, and drug discovery efforts and will allow deeper insights into telomere biology.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.ado0431

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