Affiliation:
1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Abstract
Bacterial-fungal interactions have great environmental, medical, and economic importance, yet few have been well characterized at the molecular level. Here, we describe a pathogenic interaction between
Pseudomonas aeruginosa
and
Candida albicans
, two opportunistic pathogens.
P. aeruginosa
forms a dense biofilm on
C. albicans
filaments and kills the fungus. In contrast,
P. aeruginosa
neither binds to nor kills yeast-form
C. albicans
. Several
P. aeruginosa
virulence factors that are important in disease are involved in the killing of
C. albicans
filaments. We propose that many virulence factors studied in the context of human infection may also have a role in bacterial-fungal interactions.
Publisher
American Association for the Advancement of Science (AAAS)
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