A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy-Reference-Cited by-同舟云学术

A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Published:2022-05-27 Issue:6596 Volume:376 Page:1006-1012
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Choi Yeon Sik¹²³^ORCID,Jeong Hyoyoung¹²^ORCID,Yin Rose T.⁴^ORCID,Avila Raudel⁵,Pfenniger Anna⁶^ORCID,Yoo Jaeyoung¹²^ORCID,Lee Jong Yoon¹²⁷^ORCID,Tzavelis Andreas¹²⁸⁹^ORCID,Lee Young Joong¹²^ORCID,Chen Sheena W.¹⁰¹¹^ORCID,Knight Helen S.⁴^ORCID,Kim Seungyeob¹²¹²^ORCID,Ahn Hak-Young¹²³^ORCID,Wickerson Grace¹²¹³^ORCID,Vázquez-Guardado Abraham¹²^ORCID,Higbee-Dempsey Elizabeth¹⁴^ORCID,Russo Bender A.⁴^ORCID,Napolitano Michael A.¹⁰¹¹^ORCID,Holleran Timothy J.¹⁰¹¹,Razzak Leen Abdul¹²⁸^ORCID,Miniovich Alana N.⁴^ORCID,Lee Geumbee¹²,Geist Beth⁶^ORCID,Kim Brandon⁷^ORCID,Han Shuling¹⁵¹⁶,Brennan Jaclyn A.⁴^ORCID,Aras Kedar⁴^ORCID,Kwak Sung Soo¹²^ORCID,Kim Joohee¹²^ORCID,Waters Emily Alexandria⁸¹⁷^ORCID,Yang Xiangxing¹⁸^ORCID,Burrell Amy⁶,San Chun Keum¹⁸^ORCID,Liu Claire¹²⁸^ORCID,Wu Changsheng¹²,Rwei Alina Y.¹⁹,Spann Alisha N.¹⁷^ORCID,Banks Anthony¹²^ORCID,Johnson David⁶^ORCID,Zhang Zheng Jenny¹⁵¹⁶^ORCID,Haney Chad R.⁸¹⁷^ORCID,Jin Sung Hun¹²¹²^ORCID,Sahakian Alan Varteres⁸²⁰^ORCID,Huang Yonggang¹³⁵²¹^ORCID,Trachiotis Gregory D.¹¹^ORCID,Knight Bradley P.⁶,Arora Rishi K.⁶,Efimov Igor R.²⁴^ORCID,Rogers John A.¹²⁵⁸¹³^ORCID

Affiliation:

1. Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

2. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.

3. Precision Biology Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea.

4. Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.

5. Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

6. Feinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.

7. Sibel Health, Niles, IL 60714, USA.

8. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

9. Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

10. Department of General Surgery, The George Washington University, Washington, DC 20052, USA.

11. Department of Cardiothoracic Surgery, Veteran Affairs Medical Center, Washington, DC 20422, USA.

12. Department of Electronic Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 406-772, Republic of Korea.

13. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

14. Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.

15. Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

16. Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

17. Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA.

18. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712, USA.

19. Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, Netherlands.

20. Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL 60208, USA.

21. Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

Abstract

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. Device Sensing

2. Continuous glucose monitoring and closed-loop systems

3. A wireless closed-loop system for optogenetic peripheral neuromodulation

4. Analysis of pacemaker malfunction and complications of temporary pacing in the coronary care unit

5. Temporary Transvenous Pacemaker Therapy: An Analysis of Complications

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