Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Author:
Gandal Michael J.1234ORCID, Haney Jillian R.123, Parikshak Neelroop N.123ORCID, Leppa Virpi123, Ramaswami Gokul123ORCID, Hartl Chris123, Schork Andrew J.5ORCID, Appadurai Vivek5ORCID, Buil Alfonso5ORCID, Werge Thomas M.567ORCID, Liu Chunyu89ORCID, White Kevin P.1011ORCID, Horvath Steve3ORCID, Geschwind Daniel H.123ORCID, Sestan Nenad, Vaccarino Flora, Gerstein Mark, Weissman Sherman, Pochareddy Sirisha, State Matthew, Knowles James, Farnham Peggy, Akbarian Schahram, Pinto Dalila, Van Baekl Harm, Dracheva Stella, Jaffe Andrew, Hyde Thomas, Zandi Peter, Crawford Gregory, Sullivan Pat, Thompson Wesley Kurt, Mortensen Preben Bo, Agerbo Esben, Pedersen Marianne Giørtz, Pedersen Carsten Bøcker, Mors Ole, Børglum Anders D., Nordentoft Merete, Hougaard David M., Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Martin Alicia R., Dumont Ashley, Stevens Christine, Churchhouse Claire, Howrigan Daniel P., Palmer Duncan S., Robinson Elise B., Satterstrom Kyle F., Cerrato Felecia, Huang Hailiang, Goldstein Jacqueline, Moran Jennifer, Julian Joanna Martin, Kimberly Maller, Patrick Chambert, Turley Patrick, Walters Raymond, Belliveau Rich, Ripke Stephan, Poterba Timothy, Daly Mark J., Neale Benjamin, Fromer Menachem, Roussos Panos, Johnson Jessica S., Shah Hardik R., Mahajan Milind C., Schadt Eric, Haroutunian Vahram, Ruderfer Douglas M., Buxbaum Joseph D., Sieberts Solveig K., Dang Kristen, Logsdon Ben, Mangravite Lara M., Peters Mette, Gur Raquel E., Hahn Chang-Gyu, Devlin Bernie, Klei Lambertus L., Lewis David, Lipska Barbara, Hirai Keisuke, Toyoshiba Hiroyoshi, Domenici Enrico, , ,
Affiliation:
1. Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. 2. Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA. 3. Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. 4. Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA. 5. Institute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen, Denmark. 6. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark. 7. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 8. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60607, USA. 9. The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China. 10. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. 11. Tempus Labs, 600 W. Chicago Avenue, Chicago, IL 60654, USA.
Abstract
Genes overlap across psychiatric disease
Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which the genetic underpinnings of these diseases differ or overlap is unknown. Gandal
et al.
performed meta-analyses of transcriptomic studies covering five major psychiatric disorders and compared cases and controls to identify coexpressed gene modules. From this, they found that some psychiatric disorders share global gene expression patterns. This overlap in polygenic traits in neuropsychiatric disorders may allow for better diagnosis and treatment.
Science
, this issue p.
693
Funder
National Institute of Mental Health Simons Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
803 articles.
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