Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants-Reference-Cited by-同舟云学术

Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

Published:1999-07-30 Issue:5428 Volume:285 Page:754-756
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brüstle Oliver¹,Jones Kimberly N.¹²,Learish Randall D.³,Karram Khalad¹,Choudhary Khalid¹²,Wiestler Otmar D.¹,Duncan Ian D.³,McKay Ronald D. G.²

Affiliation:

1. Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.

2. Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892–4092, USA.

3. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.

Abstract

Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell–derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type–specific somatic precursors for neural transplantation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

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4. Derivation of pluripotent stem cells from cultured human primordial germ cells

5. Viable offspring derived from fetal and adult mammalian cells

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