A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

Author:

Cruz-Migoni Abimael1,Hautbergue Guillaume M.1,Artymiuk Peter J.1,Baker Patrick J.1,Bokori-Brown Monika2,Chang Chung-Te1,Dickman Mark J.3,Essex-Lopresti Angela4,Harding Sarah V.4,Mahadi Nor Muhammad5,Marshall Laura E.4,Mobbs George W.1,Mohamed Rahmah56,Nathan Sheila56,Ngugi Sarah A.4,Ong Catherine7,Ooi Wen Fong8,Partridge Lynda J.1,Phillips Helen L.3,Raih M. Firdaus6,Ruzheinikov Sergei1,Sarkar-Tyson Mitali4,Sedelnikova Svetlana E.1,Smither Sophie J.4,Tan Patrick8,Titball Richard W.2,Wilson Stuart A.1,Rice David W.1

Affiliation:

1. Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK.

2. College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, UK.

3. Department of Chemical and Biological Engineering, Chemical Engineering at the Life Science Interface Institute, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.

4. Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK.

5. Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysia.

6. Faculty of Science and Technology, School of Biosciences and Biotechnology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor DE, Malaysia.

7. Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, 117510, Singapore.

8. Genome Institute of Singapore, 60 Biopolis Street, 138672, Singapore.

Abstract

A toxin associated with a disease often observed in Vietnam veterans is identified and characterized.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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