Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity-Reference-Cited by-同舟云学术

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Published:2020-11-27 Issue:6520 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shrock Ellen¹²^ORCID,Fujimura Eric¹²³^ORCID,Kula Tomasz¹²^ORCID,Timms Richard T.¹²^ORCID,Lee I-Hsiu⁴^ORCID,Leng Yumei¹²^ORCID,Robinson Matthew L.⁵^ORCID,Sie Brandon M.¹²^ORCID,Li Mamie Z.¹²^ORCID,Chen Yuezhou⁶⁷,Logue Jennifer⁸,Zuiani Adam⁶⁷^ORCID,McCulloch Denise⁸^ORCID,Lelis Felipe J. N.⁶⁷^ORCID,Henson Stephanie⁹,Monaco Daniel R.⁹,Travers Meghan⁶⁷^ORCID,Habibi Shaghayegh⁶⁷^ORCID,Clarke William A.¹⁰,Caturegli Patrizio¹¹,Laeyendecker Oliver⁵¹²,Piechocka-Trocha Alicja⁷¹³^ORCID,Li Jonathan Z.⁷¹⁴^ORCID,Khatri Ashok¹⁵^ORCID,Chu Helen Y.⁸,Villani Alexandra-Chloé¹⁶^ORCID,Kays Kyle¹⁷,Goldberg Marcia B.¹⁸^ORCID,Hacohen Nir¹⁹^ORCID,Filbin Michael R.¹⁷^ORCID,Yu Xu G.⁷¹⁴²⁰²¹^ORCID,Walker Bruce D.⁷¹³²²^ORCID,Wesemann Duane R.⁶⁷^ORCID,Larman H. Benjamin⁹,Lederer James A.²³,Elledge Stephen J.¹²⁷^ORCID,Lavin-Parsons Kendall,Parry Blair,Lilley Brendan,Lodenstein Carl,McKaig Brenna,Charland Nicole,Khanna Hargun,Margolin Justin,Gonye Anna,Gushterova Irena,Lasalle Tom,Sharma Nihaarika,Russo Brian C.,Rojas-Lopez Maricarmen,Sade-Feldman Moshe,Manakongtreecheep Kasidet,Tantivit Jessica,Thomas Molly Fisher,Abayneh Betelihem A.,Allen Patrick,Antille Diane,Armstrong Katrina,Boyce Siobhan,Braley Joan,Branch Karen,Broderick Katherine,Carney Julia,Chan Andrew,Davidson Susan,Dougan Michael,Drew David,Elliman Ashley,Flaherty Keith,Flannery Jeanne,Forde Pamela,Gettings Elise,Griffin Amanda,Grimmel Sheila,Grinke Kathleen,Hall Kathryn,Healy Meg,Henault Deborah,Holland Grace,Kayitesi Chantal,LaValle Vlasta,Lu Yuting,Luthern Sarah,Marchewka (Schneider) Jordan,Martino Brittani,McNamara Roseann,Nambu Christian,Nelson Susan,Noone Marjorie,Ommerborn Christine,Pacheco Lois Chris,Phan Nicole,Porto Falisha A.,Ryan Edward,Selleck Kathleen,Slaughenhaupt Sue,Sheppard Kimberly Smith,Suschana Elizabeth,Wilson Vivine,Alter Galit,Balazs Alejandro,Bals Julia,Barbash Max,Bartsch Yannic,Boucau Julie,Chevalier Josh,Chowdhury Fatema,Einkauf Kevin,Fallon Jon,Fedirko Liz,Finn Kelsey,Garcia-Broncano Pilar,Hartana Ciputra,Jiang Chenyang,Kaplonek Paulina,Karpell Marshall,Lam Evan C.,Lefteri Kristina,Lian Xiaodong,Lichterfeld Mathias,Lingwood Daniel,Liu Hang,Liu Jinqing,Ly Natasha,Michell Ashlin,Millstrom Ilan,Miranda Noah,O’Callaghan Claire,Osborn Matthew,Pillai Shiv,Rassadkina Yelizaveta,Reissis Alexandra,Ruzicka Francis,Seiger Kyra,Sessa Libera,Sharr Christianne,Shin Sally,Singh Nishant,Sun Weiwei,Sun Xiaoming,Ticheli Hannah,Trocha-Piechocka Alicja,Worrall Daniel,Zhu Alex,Daley George,Golan David,Heller Howard,Sharpe Arlene,Jilg Nikolaus,Rosenthal Alex,Wong Colline,

Affiliation:

1. Department of Genetics, Harvard Medical School, Boston, MA, USA.

2. Howard Hughes Medical Institute, Division of Genetics, Brigham and Women’s Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA.

3. Chemical Biology Program, Harvard University, Cambridge, MA, USA.

4. Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

5. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

6. Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

7. Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.

8. Department of Medicine, University of Washington, Seattle, WA, USA.

9. Institute for Cell Engineering, Immunology Division, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

10. Division of Clinical Chemistry, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

11. Division of Immunology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

12. Division of Intramural Research, NIAID, NIH, Baltimore, MD, USA.

13. Howard Hughes Medical Institute, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

14. Infectious Disease Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA.

15. Endocrine Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

16. Massachusetts General Hospital Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.

17. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

18. Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine and Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

19. Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.

20. Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

21. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

22. Centre for the AIDS Programme of Research in South Africa, Congella, South Africa.

23. Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections. Shrock et al. used a technology known as VirScan to probe the antibody repertoires of hundreds of coronavirus disease 2019 (COVID-19) patients and pre–COVID-19 era controls. They identified hundreds of antibody targets, including several antibody epitopes shared by the mild and severe coronaviruses and many specific to SARS-CoV-2. A machine-learning model accurately classified patients infected with SARS-CoV-2 and guided the design of an assay for rapid SARS-CoV-2 antibody detection. The study also looked at how the antibody response and viral exposure history differ in patients with diverging outcomes, which could inform the production of improved vaccine and antibody therapies. Science , this issue p. eabd4250

Funder

National Institutes of Health

National Cancer Institute

MassCPR

U.S. Department of Defense

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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