Clues to the Pathogenesis of Familial Colorectal Cancer

Author:

Aaltonen Lauri A.1,Peltomäki Päivi1,Leach Fredrick S.2,Sistonen Pertti3,Pylkkänen Lea1,Mecklin Jukka-Pekka4,Järvinen Heikki5,Powell Steven M.2,Jen Jin2,Hamilton Stanley R.2,Petersen Gloria M.2,Kinzler Kenneth W.2,Vogelstein Bert2,de la Chapelle Albert1

Affiliation:

1. Department of Medical Genetics, University of Helsinki, SF-00014 Helsinki, Finland.

2. Departments of Oncology, Pathology, Surgery, and Epidemiology, Johns Hopkins University School of Medicine and School of Public Health and Hygiene, and Johns Hopkins Hospital, Baltimore, MD 21231.

3. Department of Medical Sciences, University of Helsinki, and Finnish Red Cross Blood Transfusion Service, SF-00310 Helsinki, Finland.

4. Department of Surgery, Jyvdskyla Central Hospital, SF-40620 Jyvaskyla, Finland.

5. Second Department of Surgery, Helsinki University Central Hospital, SF-00290 Helsinki, Finland.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Prevalence of ras gene mutations in human colorectal cancers

2. CAMPO, E, LOSS OF HETEROZYGOSITY OF P53-GENE AND P53-PROTEIN EXPRESSION IN HUMAN COLORECTAL CARCINOMAS, CANCER RESEARCH 51: 4436 (1991).

3. Triplet Repeat Mutations in Human Disease

4. CLEAVER, J.E., DEFECTIVE REPAIR REPLICATION OF DNA IN XERODERMA PIGMENTOSUM, NATURE 218: 652 (1968).

5. DUNLOP, M.G., SCREENING FOR LARGE-BOWEL NEOPLASMS IN INDIVIDUALS WITH A FAMILY HISTORY OF COLORECTAL-CANCER, BRITISH JOURNAL OF SURGERY 79: 488 (1992).

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