A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins-Reference-Cited by-同舟云学术

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

Published:2011-08-12 Issue:6044 Volume:333 Page:850-856
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Corti Davide¹²,Voss Jarrod³,Gamblin Steven J.³,Codoni Giosiana¹,Macagno Annalisa¹,Jarrossay David¹,Vachieri Sebastien G.³,Pinna Debora¹,Minola Andrea¹,Vanzetta Fabrizia²,Silacci Chiara¹,Fernandez-Rodriguez Blanca M.¹,Agatic Gloria²,Bianchi Siro²,Giacchetto-Sasselli Isabella¹,Calder Lesley³,Sallusto Federica¹,Collins Patrick³,Haire Lesley F.³,Temperton Nigel⁴,Langedijk Johannes P. M.⁵,Skehel John J.³,Lanzavecchia Antonio¹⁶

Affiliation:

1. Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland.

2. Humabs BioMed SA, 6500 Bellinzona, Switzerland.

3. Medical Research Council (MRC) National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

4. Viral Pseudotype Unit, School of Pharmacy, University of Kent, Kent ME4 4TB, UK.

5. Pepscan Therapeutics BV, Lelystad, 8243 RC, Netherlands.

6. Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, 8032 Zürich, Switzerland.

Abstract

An antibody able to broadly neutralize both group 1 and group 2 influenza A viruses—and its target epitope—are identified.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

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3. Evolution and ecology of influenza A viruses

4. The Global Circulation of Seasonal Influenza A (H3N2) Viruses

5. Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

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