Hierarchical Genetic Organization of Human Cortical Surface Area-Reference-Cited by-同舟云学术

Hierarchical Genetic Organization of Human Cortical Surface Area

Published:2012-03-30 Issue:6076 Volume:335 Page:1634-1636
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Chi-Hua¹,Gutierrez E. D.²,Thompson Wes¹,Panizzon Matthew S.¹,Jernigan Terry L.¹²,Eyler Lisa T.¹³,Fennema-Notestine Christine¹⁴,Jak Amy J.¹⁵,Neale Michael C.⁶,Franz Carol E.¹⁷,Lyons Michael J.⁸,Grant Michael D.⁸,Fischl Bruce⁹,Seidman Larry J.¹⁰,Tsuang Ming T.¹⁵⁶,Kremen William S.¹⁵⁶,Dale Anders M.¹⁴¹¹

Affiliation:

1. Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.

2. Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA.

3. Veterans Administration (VA) San Diego Healthcare System, San Diego, CA 92161, USA.

4. Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA.

5. VA Center of Excellence for Stress and Mental Health, San Diego, CA 92093, USA.

6. Departments of Psychiatry and Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA.

7. Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093, USA.

8. Department of Psychology, Boston University, Boston, MA 02215, USA.

9. Department of Radiology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02115, USA.

10. Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.

11. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Building the Brain Brain connectivity is often described as a network of discrete independent cables analogous to a switchboard, but how is the physical structure of the brain constructed (see the Perspective by

Zilles and Amunts

)? Wedeen et al. (p. 1628 ) used high-resolution diffusion tensor imaging in humans and four species of nonhuman primates to identify and compare the geometric structure of large fiber tracts in the brain. Fiber tracts followed a highly constrained and regular geometry, which may provide an efficient solution for pathfinding during ontogenetic development. Much of development occurs through elaboration and assembly of semiautonomous building blocks. Chen et al. (p. 1634 ) applied statistical analysis to the form of the human cortex in brain-imaging studies that compared more than 400 di- and mono-zygotic twins. The findings suggest that the structure of the human cortex is defined by genetics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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