Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease-Reference-Cited by-同舟云学术

Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease

Published:2006-10-06 Issue:5796 Volume:314 Page:133-136
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mathiason Candace K.¹²³⁴⁵,Powers Jenny G.¹²³⁴⁵,Dahmes Sallie J.¹²³⁴⁵,Osborn David A.¹²³⁴⁵,Miller Karl V.¹²³⁴⁵,Warren Robert J.¹²³⁴⁵,Mason Gary L.¹²³⁴⁵,Hays Sheila A.¹²³⁴⁵,Hayes-Klug Jeanette¹²³⁴⁵,Seelig Davis M.¹²³⁴⁵,Wild Margaret A.¹²³⁴⁵,Wolfe Lisa L.¹²³⁴⁵,Spraker Terry R.¹²³⁴⁵,Miller Michael W.¹²³⁴⁵,Sigurdson Christina J.¹²³⁴⁵,Telling Glenn C.¹²³⁴⁵,Hoover Edward A.¹²³⁴⁵

Affiliation:

1. Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biological Sciences (CVMBS), Colorado State University (CSU), Fort Collins, CO 80523, USA.

2. Veterinary Diagnostic Laboratory, College of Veterinary Medicine and Biological Sciences (CVMBS), Colorado State University (CSU), Fort Collins, CO 80523, USA.

3. Biological Resource Management Division, National Park Service, Fort Collins, CO 80525, USA.

4. Wildlife Artist Supply Company (WASCO) Inc., Monroe, GA 30655, USA.

5. Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30609, USA.

Abstract

A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-naiÌve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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