An ingestible self-orienting system for oral delivery of macromolecules-Reference-Cited by-同舟云学术

An ingestible self-orienting system for oral delivery of macromolecules

Published:2019-02-08 Issue:6427 Volume:363 Page:611-615
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Abramson Alex¹^ORCID,Caffarel-Salvador Ester¹²^ORCID,Khang Minsoo¹^ORCID,Dellal David²^ORCID,Silverstein David¹^ORCID,Gao Yuan¹^ORCID,Frederiksen Morten Revsgaard³^ORCID,Vegge Andreas³,Hubálek František³^ORCID,Water Jorrit J.³^ORCID,Friderichsen Anders V.³^ORCID,Fels Johannes³^ORCID,Kirk Rikke Kaae³,Cleveland Cody¹³^ORCID,Collins Joy¹^ORCID,Tamang Siddartha¹,Hayward Alison¹⁴^ORCID,Landh Tomas³,Buckley Stephen T.³^ORCID,Roxhed Niclas¹⁵^ORCID,Rahbek Ulrik³^ORCID,Langer Robert¹²⁶^ORCID,Traverso Giovanni¹⁷⁸^ORCID

Affiliation:

1. Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

4. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.

6. Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Delivering fragile drugs to the gut Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar casing allowed for triggered actuation for the delivery of biomolecules. The approach successfully provided active insulin delivery in pigs. Science , this issue p. 611

Funder

National Science Foundation

National Institutes of Health

Brigham and Women’s Hospital

Massachusetts Institute of Technology

Novo Nordisk

Viking Olaf Bjork Scholarship Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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