Architecture of African swine fever virus and implications for viral assembly-Reference-Cited by-同舟云学术

Architecture of African swine fever virus and implications for viral assembly

Published:2019-11 Issue:6465 Volume:366 Page:640-644
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Nan¹²^ORCID,Zhao Dongming³^ORCID,Wang Jialing¹²^ORCID,Zhang Yangling¹²^ORCID,Wang Ming³,Gao Yan⁴⁵,Li Fang³,Wang Jingfei³^ORCID,Bu Zhigao³^ORCID,Rao Zihe¹⁴⁵⁶^ORCID,Wang Xiangxi¹²^ORCID

Affiliation:

1. CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

2. University of Chinese Academy of Sciences, Beijing 100049, China.

3. State Key Laboratory of Veterinary Biotechnology and National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

4. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

5. Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China.

6. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300353, China.

Abstract

Unveiling African swine fever virus African swine fever virus (ASFV) is highly contagious and often lethal. With no vaccine or effective treatment, infections often require large-scale culling of pigs. Wang et al. apply cutting-edge cryo–electron microscopy techniques to determine the structure of this very large DNA virus. An 8.8-angstrom-resolution reconstruction shows the five layers of the virus, and the fourth capsid layer could be reconstructed at 4.8-angstrom resolution. The structure reveals epitopes in the major capsid protein that distinguish ASFV from other nucleocytoplasmic large DNA viruses and shows how the minor capsid proteins stabilize the capsid. Science , this issue p. 640

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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