Affiliation:
1. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143–0448, USA.
Abstract
The germ line of the nematode
Caenorhabditis elegans
influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.
Publisher
American Association for the Advancement of Science (AAAS)
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