High-fructose corn syrup enhances intestinal tumor growth in mice-Reference-Cited by-同舟云学术

High-fructose corn syrup enhances intestinal tumor growth in mice

Published:2019-03-22 Issue:6433 Volume:363 Page:1345-1349
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Goncalves Marcus D.¹²^ORCID,Lu Changyuan³^ORCID,Tutnauer Jordan¹,Hartman Travis E.⁴^ORCID,Hwang Seo-Kyoung¹^ORCID,Murphy Charles J¹⁵^ORCID,Pauli Chantal⁶,Morris Roxanne⁴^ORCID,Taylor Sam¹,Bosch Kaitlyn⁷^ORCID,Yang Sukjin⁸^ORCID,Wang Yumei⁸^ORCID,Van Riper Justin⁸^ORCID,Lekaye H Carl⁹^ORCID,Roper Jatin¹⁰^ORCID,Kim Young¹¹^ORCID,Chen Qiuying³^ORCID,Gross Steven S.³,Rhee Kyu Y.⁴,Cantley Lewis C.¹^ORCID,Yun Jihye⁸^ORCID

Affiliation:

1. Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

2. Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

3. Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.

4. Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

5. Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

6. Institute for Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

7. Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

8. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

9. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

10. Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC 27708, USA.

11. Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Abstract

A sweetener's not-so-sweet effects Obesity increases an individual's risk of developing many types of cancer, including colorectal cancer. One of the factors driving the rise in obesity rates is thought to be the use of high-fructose corn syrup (HFCS) as a sweetener in soft drinks. Goncalves et al. found that ingestion of HFCS promotes the growth of intestinal cancer even in the absence of obesity in mouse tumor models. An enzyme in tumors (ketohexokinase) converts fructose to fructose-1-phosphate, which alters tumor cell metabolism and leads to enhanced cell growth. Whether a similar process occurs in humans remains to be seen. Science , this issue p. 1345

Funder

National Institutes of Health

National Cancer Institute

National Institute of Child Health and Human Development

Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant

Cancer Prevention and Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

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