Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches-Reference-Cited by-同舟云学术

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Published:2019-03-15 Issue:6432 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chakarov Svetoslav¹^ORCID,Lim Hwee Ying²^ORCID,Tan Leonard¹^ORCID,Lim Sheau Yng²^ORCID,See Peter¹^ORCID,Lum Josephine¹^ORCID,Zhang Xiao-Meng¹,Foo Shihui¹^ORCID,Nakamizo Satoshi¹,Duan Kaibo¹,Kong Wan Ting¹,Gentek Rebecca³^ORCID,Balachander Akhila¹,Carbajo Daniel¹,Bleriot Camille¹,Malleret Benoit¹²^ORCID,Tam John Kit Chung⁴^ORCID,Baig Sonia⁵^ORCID,Shabeer Muhammad⁵,Toh Sue-Anne Ee Shiow⁵,Schlitzer Andreas⁶,Larbi Anis¹,Marichal Thomas⁷⁸⁹^ORCID,Malissen Bernard³¹⁰,Chen Jinmiao¹^ORCID,Poidinger Michael¹^ORCID,Kabashima Kenji¹¹¹^ORCID,Bajenoff Marc³,Ng Lai Guan¹,Angeli Veronique²^ORCID,Ginhoux Florent¹^ORCID

Affiliation:

1. Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.

2. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

3. Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.

4. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore.

5. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore, Singapore.

6. Myeloid Cell Biology, Life & Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.

7. Laboratory of Cellular and Molecular Immunology, GIGA Research, University of Liège, 4000 Liège, Belgium.

8. Faculty of Veterinary Medicine, Liège University, 4000 Liège, Belgium.

9. WELBIO, Walloon Excellence in Life Sciences and Biotechnology, 1300 Wallonia, Belgium.

10. Centre d’Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, 13288 Marseille, France.

11. Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Abstract

Tissue macrophages have a split personality Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. Science , this issue p. eaau0964 ; see also p. 1154

Funder

AXA Research Fund

Singapore Immunology Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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