Developmental clock and mechanism of de novo polarization of the mouse embryo

Author:

Zhu Meng1ORCID,Cornwall-Scoones Jake2ORCID,Wang Peizhe3,Handford Charlotte E.14,Na Jie3ORCID,Thomson Matt2,Zernicka-Goetz Magdalena124ORCID

Affiliation:

1. Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

2. Division of Biology and Biological Engineering, California Institute of Technology (Caltech), Pasadena, CA 91125, USA.

3. Centre for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.

4. Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK.

Abstract

Timing and trigger of cell polarization During mammalian embryo development, the first cell fate decision separates the progenitors of the trophectoderm (destined to form the placenta) from the inner cell mass (which forms all tissues of the embryonic and yolk sac). A key event for this first lineage segregation is the establishment of apicobasal cell polarity. This event is set to occur at a fixed developmental stage. The factors that trigger the establishment of cell polarity as well as its temporal regulation have remained unknown. Zhu et al. show in mouse embryos that three molecular regulators—Tfap2c, Tead4, and RhoA—are sufficient to advance the timing of cell polarization with subsequent cell fate specification and morphogenesis. Science , this issue p. eabd2703

Funder

National Institutes of Health

David and Lucile Packard Foundation

Gordon and Betty Moore Foundation

H2020 European Research Council

Heritage Medical Research Institute

Open Philanthropy Project

National Key Research and Development Program of China Stem Cell and Translational Research

Wellcome Trust Centre for Mitochondrial Research

Curci and Weston Havens Foundations

Leverhulme Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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