Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals-Reference-Cited by-同舟云学术

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals

Published:2020-03-20 Issue:6484 Volume:367 Page:1372-1376
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Jia¹^ORCID,Kim Yoon Seok²^ORCID,Richardson Claire E.³^ORCID,Tom Ariane²^ORCID,Ramakrishnan Charu²^ORCID,Birey Fikri⁴^ORCID,Katsumata Toru¹^ORCID,Chen Shucheng¹^ORCID,Wang Cheng⁵^ORCID,Wang Xiao²^ORCID,Joubert Lydia-Marie⁶^ORCID,Jiang Yuanwen¹^ORCID,Wang Huiliang²,Fenno Lief E.²⁴^ORCID,Tok Jeffrey B.-H.¹^ORCID,Pașca Sergiu P.⁴^ORCID,Shen Kang³⁷,Bao Zhenan¹^ORCID,Deisseroth Karl²⁴⁷^ORCID

Affiliation:

1. Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

3. Department of Biology, Stanford University, Stanford, CA 94305, USA.

4. Department of Psychiatry, Stanford University, Stanford, CA 94305, USA.

5. Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley CA 94720, USA.

6. Cell Sciences Imaging Facility, Stanford University, Stanford, CA 94305, USA.

7. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Abstract

From genetics to material to behavior Introducing new genes into an organism can endow new biochemical functions or change the patterns of existing functions, but extending these manipulations to structure at the tissue level is challenging. Combining genetic engineering and polymer chemistry, Liu et al. directly leveraged complex cellular architectures of living organisms to synthesize, fabricate, and assemble bioelectronic materials (see the Perspective by Otto and Schmidt). An engineered enzyme expressed in genetically targeted neurons synthesized conductive polymers in tissues of freely moving animals. These polymers enabled modulation of membrane properties in specific neuron populations and manipulation of behavior in living animals. Science , this issue p. 1372 ; see also p. 1303

Funder

Howard Hughes Medical Institute

NIH Office of the Director

Stanford University BioX seed funding

Stanford University Wu Tsai Neuroscience Institute Big Idea Funding

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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