Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection-Reference-Cited by-同舟云学术

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

Published:2018-03-23 Issue:6382 Volume:359 Page:1376-1383
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thaiss Christoph A.¹,Levy Maayan¹,Grosheva Inna²,Zheng Danping¹,Soffer Eliran¹,Blacher Eran¹,Braverman Sofia¹,Tengeler Anouk C.¹^ORCID,Barak Oren¹³,Elazar Maya¹,Ben-Zeev Rotem¹^ORCID,Lehavi-Regev Dana¹^ORCID,Katz Meirav N.¹,Pevsner-Fischer Meirav¹^ORCID,Gertler Arieh⁴,Halpern Zamir⁵⁶⁷,Harmelin Alon⁸^ORCID,Aamar Suhail⁹,Serradas Patricia¹⁰,Grosfeld Alexandra¹⁰,Shapiro Hagit¹,Geiger Benjamin²^ORCID,Elinav Eran¹^ORCID

Affiliation:

1. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

2. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

3. Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, affiliated with the Hebrew University and Hadassah School of Medicine, Jerusalem, Israel.

4. The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, Israel.

5. Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

6. Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

7. Digestive Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

8. Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.

9. Department of Medicine, Hadassah–Hebrew University Hospital, Jerusalem, Israel.

10. INSERM Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Cités, UPD Univ. Paris 05, CNRS, IHU ICAN, Paris, France.

Abstract

Metabolic syndrome, leaky guts, and infection Metabolic syndrome often accompanies obesity and hyperglycemia and is associated with a breakdown in the integrity of the intestinal barrier and increased risk of systemic infection. Thaiss et al. found that mice with systemic infection of a Salmonella analog, Citrobacter rodentium , also exhibited hyperglycemia. Deletion of the glucose transporter GLUT2 altered sensitivity to chemically induced epithelial permeability and protected mice from pathogen invasion. The authors also found a correlation in humans between glycated hemoglobin (an indicator of hyperglycemia) and serum levels of pathogen recognition receptor ligands. Science , this issue p. 1376

Funder

Bill & Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

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