A subcellular map of the human proteome-Reference-Cited by-同舟云学术

A subcellular map of the human proteome

Published:2017-05-26 Issue:6340 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thul Peter J.¹^ORCID,Åkesson Lovisa¹^ORCID,Wiking Mikaela¹^ORCID,Mahdessian Diana¹^ORCID,Geladaki Aikaterini²³^ORCID,Ait Blal Hammou¹,Alm Tove¹^ORCID,Asplund Anna⁴,Björk Lars¹^ORCID,Breckels Lisa M.²⁵^ORCID,Bäckström Anna¹,Danielsson Frida¹,Fagerberg Linn¹^ORCID,Fall Jenny¹,Gatto Laurent²⁵^ORCID,Gnann Christian¹,Hober Sophia⁶,Hjelmare Martin¹^ORCID,Johansson Fredric¹^ORCID,Lee Sunjae¹^ORCID,Lindskog Cecilia⁴,Mulder Jan⁷^ORCID,Mulvey Claire M.²^ORCID,Nilsson Peter¹^ORCID,Oksvold Per¹^ORCID,Rockberg Johan⁶^ORCID,Schutten Rutger¹^ORCID,Schwenk Jochen M.¹^ORCID,Sivertsson Åsa¹^ORCID,Sjöstedt Evelina⁴^ORCID,Skogs Marie¹,Stadler Charlotte¹^ORCID,Sullivan Devin P.¹^ORCID,Tegel Hanna⁶^ORCID,Winsnes Casper¹^ORCID,Zhang Cheng¹^ORCID,Zwahlen Martin¹^ORCID,Mardinoglu Adil¹^ORCID,Pontén Fredrik⁴^ORCID,von Feilitzen Kalle¹,Lilley Kathryn S.²,Uhlén Mathias¹^ORCID,Lundberg Emma¹^ORCID

Affiliation:

1. Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.

2. Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

3. Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

4. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.

5. Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

6. Department of Proteomics, School of Biotechnology, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.

7. Science for Life Laboratory, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Abstract

Mapping the proteome Proteins function in the context of their environment, so an understanding of cellular processes requires a knowledge of protein localization. Thul et al. used immunofluorescence microscopy to map 12,003 human proteins at a single-cell level into 30 cellular compartments and substructures (see the Perspective by Horwitz and Johnson). They validated their results by mass spectroscopy and used them to model and refine protein-protein interaction networks. The cellular proteome is highly spatiotemporally regulated. Many proteins localize to multiple compartments, and many show cell-to-cell variation in their expression patterns. Presented as an interactive database called the Cell Atlas, this work provides an important resource for ongoing efforts to understand human biology. Science , this issue p. eaal3321 ; see also p. 806

Funder

Familjen Erling-Perssons Stiftelse

Knut och Alice Wallenbergs Stiftelse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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