Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex-Reference-Cited by-同舟云学术

Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex

Published:1997-08-15 Issue:5328 Volume:277 Page:968-971
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rainville Pierre¹²³⁴⁵,Duncan Gary H.¹²³⁴⁵,Price Donald D.¹²³⁴⁵,Carrier Benoı̂t¹²³⁴⁵,Bushnell M. Catherine¹²³⁴⁵

Affiliation:

1. P. Rainville, Département de Psychologie and Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montréal, Québec, Canada H3C 3J7, and McConnell Brain Imaging Center, Montreal Neurological Institute, Montréal, Québec, Canada H3A 2B4.

2. G. H. Duncan, Département de Stomatologie, Faculté de Médecine Dentaire, and Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montréal, Québec, Canada H3C 3J7, and McConnell Brain Imaging Center, Montreal Neurological Institute, Montréal, Québec, Canada.

3. D. D. Price, Department of Anesthesiology, Medical College of Virginia, Richmond, VA 23298, USA.

4. B. Carrier, Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal, Montréal, Québec, Canada H3C 3J7.

5. M. C. Bushnell, Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montréal, Québec, Canada H3C 3J7, McConnell Brain Imaging Center, Montreal Neurological Institute, Montréal, Québec, Canada, and Department of Anesthesiology, McGill University, Montréal, Québec, Canada H3A 1A1.

Abstract

Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in pain affect, hypnotic suggestions were used to alter selectively the unpleasantness of noxious stimuli, without changing the perceived intensity. Positron emission tomography revealed significant changes in pain-evoked activity within anterior cingulate cortex, consistent with the encoding of perceived unpleasantness, whereas primary somatosensory cortex activation was unaltered. These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. R. Melzack and K. L. Casey in The Skin Senses D. R. Kenshalo Ed. (Thomas Springfield IL 1968) pp. 423–443.

2. H. L. Fields Pain (McGraw-Hill New York 1987).

3. Foltz E. L., White E. W., J. Neurosurg. 19, 89 (1962);

4. ; Int. J. Neurol. 6 353 (1968);

5. Hurt R. W., Ballantine H. T., Clin. Neurosurg. 21, 334 (1973);

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