Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation-Reference-Cited by-同舟云学术

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

Published:2013-04-05 Issue:6128 Volume:340 Page:82-85
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Meijer H. A.¹,Kong Y. W.¹,Lu W. T.¹,Wilczynska A.¹,Spriggs R. V.¹,Robinson S. W.¹,Godfrey J. D.¹,Willis A. E.¹,Bushell M.¹

Affiliation:

1. Medical Research Council (MRC) Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK.

Abstract

MicroRNA Mechanism MicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82 ) show that in a HeLa cell system mRNA degradation is a consequence of translational inhibition via the initiation factor eIF4A2.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. The mechanism of eukaryotic translation initiation and principles of its regulation

2. Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

3. miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

4. Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

5. Kinetic analysis reveals successive steps leading to miRNA‐mediated silencing in mammalian cells

Cited by 282 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics;Non-coding RNA Research;2024-12

2. IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation;2024-08-27

3. Importance of core microRNA pathway genes and microRNAs associated with the defense of Odontotermes formosanus (Shiraki) against Serratia marcescens infection;Pesticide Biochemistry and Physiology;2024-05

4. Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells;Journal of Pharmacological Sciences;2024-04

5. Transcriptome-Wide Evaluation Characterization of Micrornas and Assessment of Their Functional Roles as Regulators of Diapause in Ostrinia Furnacalis Larvae (Lepidoptera: Crambidae);2024