CD8 + T Cell Cross-Priming via Transfer of Proteasome Substrates

Author:

Norbury Christopher C.123,Basta Sameh123,Donohue Keri B.123,Tscharke David C.123,Princiotta Michael F.123,Berglund Peter123,Gibbs James123,Bennink Jack R.123,Yewdell Jonathan W.123

Affiliation:

1. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.

2. Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

3. Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Abstract

“Cross-priming” describes the activation of naïve CD8 + T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from “donor” cells. Antigen transfer is believed to be mediated by donor cell–derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8 + T cell responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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