A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells-Reference-Cited by-同舟云学术

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Published:2015-06-19 Issue:6241 Volume:348 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stary Georg¹,Olive Andrew¹,Radovic-Moreno Aleksandar F.²³,Gondek David¹,Alvarez David¹,Basto Pamela A.²³,Perro Mario¹,Vrbanac Vladimir D.⁴,Tager Andrew M.⁴,Shi Jinjun⁵,Yethon Jeremy A.⁶,Farokhzad Omid C.⁵⁷,Langer Robert²³,Starnbach Michael N.¹,von Andrian Ulrich H.¹⁸

Affiliation:

1. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

2. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

5. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Sanofi Pasteur, Cambridge, MA 02139, USA.

7. King Abdulaziz University, Jeddah, Saudi Arabia.

8. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Abstract

The right combination for protection Despite its prevalence, no vaccine exists to protect against infection with the sexually transmitted bacterium Chlamydia trachomatis . Stary et al. now report on one potential vaccine candidate (see the Perspective by Brunham). Vaccinating with an ultraviolet light-inactivated C. trachomatis linked to adjuvant-containing charged nanoparticles protected female conventional and humanized mice against C. trachomatis infection. The vaccine conferred protection only when delivered through mucosal routes. Protection relied on targeting the bacteria to a particular population of immunogenic dendritic cells and inducing memory T cells that resided in the female genital tract. Science , this issue 10.1126/science.aaa8205 ; see also p. 1322

Funder

NIH

MGH

MIT

Harvard University

arvard Innovation Award from Sanofi Pasteur

David Koch Prostate Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.