Genetics of Mouse Behavior: Interactions with Laboratory Environment-Reference-Cited by-同舟云学术

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Published:1999-06-04 Issue:5420 Volume:284 Page:1670-1672
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Crabbe John C.¹,Wahlsten Douglas²,Dudek Bruce C.³

Affiliation:

1. Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR 97201, USA.

2. Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9.

3. Department of Psychology, State University of New York at Albany, Albany, NY 12222, USA.

Abstract

Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

2. Gerlai R., Trends Neurosci. 19, 177 (1996);

3. Nguyen M., et al., Nature 390, 78 (1997).

4. It has been known for some time that comparisons of multiple genotypes on learning-related tests do not always yield consistent results across laboratories [D. Wahlsten in Psychopharmacology of Aversively Motivated Behavior H. Anisman and G. Bignami Eds. (Plenum New York 1978) pp. 63–118]. For another example the Crabbe laboratory has reported that C57BL/6 mice show a small enhancement of locomotor activity after low doses of ethanol while the Dudek laboratory finds no such stimulant response [

5. Crabbe J. C., et al., J. Comp. Physiol. Psychol. 96, 440 (1982);

Cited by 1392 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Three methods of behavioural testing to measure anxiety – A review;Behavioural Processes;2024-02

2. Mice Recognise Mice in Neighbouring Rearing Cages and Change Their Social Behaviour;Behavioural Neurology;2024-01-16

3. Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature;2024-01-08

4. IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system;Frontiers in Behavioral Neuroscience;2024-01-03

5. Systematic heterogenization revisited: Increasing variation in animal experiments to improve reproducibility?;Journal of Neuroscience Methods;2024-01