Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

Author:

Snippert Hugo J.1,Haegebarth Andrea1,Kasper Maria2,Jaks Viljar2,van Es Johan H.1,Barker Nick1,van de Wetering Marc1,van den Born Maaike1,Begthel Harry1,Vries Robert G.1,Stange Daniel E.1,Toftgård Rune2,Clevers Hans1

Affiliation:

1. Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

2. Karolinska Institutet, Center for Biosciences and Department of Biosciences and Nutrition, Novum, SE-141 57 Huddinge, Sweden.

Abstract

Hair Today, Skin Tomorrow The epidermis of mammals contains hair follicles, sebaceous glands, and interfollicular epidermis, but it has not been clear how the development and repair of these structures is regulated. Snippert et al. (p. 1385 ) show that a stem-cell cluster in the hair follicle, characterized by the expression of Lgr6, a close homolog of the Lgr5 marker for stem cells in the small intestine and colon, resides directly above the hair bulge and gives rise to all cell lineages of the skin. Skin wounds in adult mice are repaired by Lgr6 stem cells in the hair follicles that flank the damage. After hair morphogenesis, Lgr6 stem cells give rise to epidermal and sebaceous gland lineages to generate fully differentiated new skin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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