Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice-Reference-Cited by-同舟云学术

Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice

Published:2013-11 Issue:6158 Volume:342 Page:637-640
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sabelström Hanna¹,Stenudd Moa¹,Réu Pedro¹²,Dias David O.¹,Elfineh Marta¹,Zdunek Sofia¹,Damberg Peter³,Göritz Christian¹,Frisén Jonas¹

Affiliation:

1. Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

2. Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.

3. Department of Clinical Science, Intervention and Technology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Abstract

The Good Scar We tend to think of scars as bad and, in the central nervous system, as counterproductive to recovery. Studying mice, Sabelström et al. (p. 637 ) prevented resident stem cells from proliferating after spinal cord injury. Without the astrocytes generated by the neural stem cells, recovery from spinal cord lesions was poorer than normal. Thus, somewhat counterintuitively, glial scarring appears to limit spinal cord damage and support the remaining cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin

2. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

3. STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

4. Overcoming Inhibition in the Damaged Spinal Cord

5. Regeneration beyond the glial scar

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