Generation of human oogonia from induced pluripotent stem cells in vitro-Reference-Cited by-同舟云学术

Generation of human oogonia from induced pluripotent stem cells in vitro

Published:2018-10-19 Issue:6412 Volume:362 Page:356-360
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yamashiro Chika¹²^ORCID,Sasaki Kotaro¹²,Yabuta Yukihiro¹²,Kojima Yoji¹²³⁴^ORCID,Nakamura Tomonori¹²^ORCID,Okamoto Ikuhiro¹²^ORCID,Yokobayashi Shihori¹²⁴,Murase Yusuke¹²,Ishikura Yukiko¹²,Shirane Kenjiro⁵⁶,Sasaki Hiroyuki⁵⁶,Yamamoto Takuya³⁴⁷^ORCID,Saitou Mitinori¹²³⁴^ORCID

Affiliation:

1. Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

2. Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO), Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

3. Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.

4. Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

5. Division of Epigenomics, Medical Institute of Bioregulation, and Epigenome Network Research Center, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

6. Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

7. Agency for Medical Research and Development–Core Research for Evolutional Science and Technology (AMED-CREST), AMED, 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.

Abstract

Reconstituting a human ovary Human pluripotent stem cells (hPSCs) have been induced into human primordial germ cell–like cells (hPGCLCs) in vitro, the first step toward human in vitro gametogenesis. Yamashiro et al. went a step closer to generating mature gametes by culturing hPSCs with mouse embryonic ovarian somatic cells in xenogeneic reconstituted ovaries (see the Perspective by Gill and Peters). Over a period of 4 months, hPGCLCs underwent hallmark epigenetic reprogramming and differentiated progressively into cells closely resembling human oogonia, an immediate embryonic precursor for human oocytes. This study creates opportunities for human germ cell research and provides a foundation for human in vitro gametogenesis. Science , this issue p. 356 ; see also p. 291

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Gametogenesis from Pluripotent Stem Cells

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3. In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells

4. Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

5. Reconstitution in vitro of the entire cycle of the mouse female germ line

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