Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4-Reference-Cited by-同舟云学术

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Published:2013-09-13 Issue:6151 Volume:341 Page:1246-1249
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kayagaki Nobuhiko¹,Wong Michael T.¹,Stowe Irma B.¹,Ramani Sree Ranjani²,Gonzalez Lino C.²,Akashi-Takamura Sachiko³,Miyake Kensuke³,Zhang Juan⁴,Lee Wyne P.⁴,Muszyński Artur⁵,Forsberg Lennart S.⁵,Carlson Russell W.⁵,Dixit Vishva M.¹

Affiliation:

1. Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

2. Department of Protein Chemistry, Genentech, South San Francisco, CA 94080, USA.

3. Division of Innate Immunity, Department of Microbiology and Immunology, Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

4. Department of Immunology, Genentech, South San Francisco, CA 94080, USA.

5. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Abstract

Move Over, TLR4 The innate immune system senses bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4) (see the Perspective by

Kagan

). However, Kayagaki et al. (p 1246 , published online 25 July) and Hagar et al. (p. 1250 ) report that the hexa-acyl lipid A component of LPS from Gramnegative bacteria is able to access the cytoplasm and activate caspase-11 to signal immune responses independently of TLR4. Mice that lack caspase-11 are resistant to LPS-induced lethality, even in the presence of TLR4.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

2. The Inflammasomes

3. Cryopyrin activates the inflammasome in response to toxins and ATP

4. Gout-associated uric acid crystals activate the NALP3 inflammasome

5. Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE

Cited by 1175 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities;Pharmacological Research;2024-03

2. IRF3 function and immunological gaps in sepsis;Frontiers in Immunology;2024-02-05

3. Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria;Poultry Science;2024-02

4. Trauma-induced innate immune activation and disseminated intravascular coagulation;Journal of Thrombosis and Haemostasis;2024-02

5. Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation;Cellular Immunology;2024-02