Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Author:

Williams Pete A.1ORCID,Harder Jeffrey M.1ORCID,Foxworth Nicole E.1ORCID,Cochran Kelly E.1ORCID,Philip Vivek M.1ORCID,Porciatti Vittorio2ORCID,Smithies Oliver3ORCID,John Simon W. M.145ORCID

Affiliation:

1. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

2. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

3. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

4. Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA.

5. The Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA.

Abstract

Vitamin B 3 protects mice from glaucoma Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is irreversible. Williams et al. now report that vitamin B 3 (also known as niacin) prevents eye degeneration in glaucoma-prone mice (see the Perspective by Crowston and Trounce). Supplementing the diets of young mice with vitamin B 3 averted early signs of glaucoma. Vitamin B 3 also halted further glaucoma development in aged mice that already showed signs of the disease. Thus, healthy intake of vitamin B 3 may protect eyesight. Science , this issue p. 756 ; see also p. 688

Funder

National Heart, Lung, and Blood Institute

National Eye Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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